After some struggles I've gotten my Qstarz BT-Q1000X working on OS X Mountain Lion over USB. Here's what I did:
1) Install the CP210x USB to UART Bridge VCP Drivers from
https://www.silabs.com/Support%20Documents/Software/Mac_OSX_VCP_Driver.zip
2) Reboot
3) Using Safari, install the latest desktop development version of BT747
http://soft.bt747.org/BT747_J2SE_Latest_Install.jnlp